Iran’s dependence on pesticide and insecticide imports, compounded by a growing population, limited arable land, and high soil erosion, has led to the call by the Ministry of Agriculture, Extension, and others for sustainable agriculture practices. The purpose of this study was to examine the perceptions of wheat farmers with respect to sustainable agriculture in Lorestan Province, Iran. Data were collected in 2000 through personal interviews with randomly selected wheat farmers. Major barriers hampering adoption of sustainable agriculture practices included: Limited financial returns for farmers, limited farmer knowledge of sustainable agriculture principles and methods, low levels of farmer education, government rules and regulations, problems with soil erosion and lack of water, and a low level of Extension agent knowledge with respect to sustainable agriculture. Recommendations include a more participatory approach to the development and delivery of Extension programs.